Setting up interactions in Webflow involves using the Interactions panel, where you can create complex animations based on various triggers. Start by selecting an element you want to animate, then click on the “Interactions” tab. From there, you can choose a trigger (e.g., page load, scroll, hover, click) and customize the animation sequence using a timeline interface. Webflow provides a range of preset animations, or you can create custom animations by adjusting properties like movement, opacity, scale, and rotation.